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Page No. : 77-88

ABSTRACT

Group A Rotavirus remains a leading cause of acute gastroenteritis in infants and young animals worldwide, posing significant public health concern due to its high morbidity and potential for zoonotic transmission. This comprehensive review explores the epidemiology and molecular characteristics of rotavirus, emphasizing the interspecies transmission pathways between humans and animals. Key factors influencing zoonotic potential, including viral genetic diversity and host susceptibility are analyzed. In addition, the paper evaluates current diagnostic methods, ranging from traditional techniques like enzyme immunoassays to advanced molecular tools such as RT-PCR. Understanding the dynamics of cross-species transmission and improving diagnostic accuracy are critical for effective surveillance, outbreak control, and the development of targeted vaccines. This review underscores the importance of a One Health approach in managing rotavirus infections globally.

Keywords: Diagnostic methods, gastroenteritis, Group A Rotavirus, one health approach, zoonotic transmission