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Page No. : 27-31

ABSTRACT

The immune response and efficacy of an inactivated tissue culture anti-rabies vaccine (Raksharab®) in two different post exposure schedules were studied in rabies exposed cattle. The study animals were grouped in to two groups. Group-1 vaccinated with anti-rabies vaccine on 0, 3rd, 7th, 14th and 28th days (Schedule-I) and Group-2 vaccinated on 0, 1st, 2nd, 3rd and 4th days continuously (Schedule-II). The rabies virus neutralizing antibody titers were assessed on days zero, 7, 14, 28, 60 and 90 by rapid fluorescent focus inhibition test- (RFFIT). Group-1 animals obtained the high mean rabies virus neutralizing antibody titers than that of group-2. Both the schedules I and II provided protective titre from 14th to 90th day of observation and none of the animals developed rabies.

Keywords: Anti-rabies vaccine, cattle, RFFIT