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Page No. : 34-39

ABSTRACT

Leptospirosis is a most widespread zoonotic illness caused by virulent Leptospira species. Leptospirosis is a systemic infection that causes renal insufficiency, hepatic dysfunction, and pulmonary failure in its most severe forms. Many Leptospirastrains show hemolytic and sphingomyelinase activity, and a variety of leptospiral hemolysin candidates have been found based on sequence similarity to well-characterized bacterial hemolysins. In present study we considered five potential phytochemical compounds of Diospyros lotus fruits against leptospiral hemolytic protein using in-silico approach. The docking results were then used to conduct comparative analyses of selected phytochemical compounds of Diospyros lotus fruits and with a standard drug tetracycline in order to determine thein silico binding affinity with leptospiral hemolysin. All the selected ligands show good results, especially Ellagic acid and Gallic acid with -8.5 and -6.2 Kcal/mol which shows low binding affinity when compare to other compounds.

Keywords: Diospyros lotus fruit, in-silico, hemolytic protein, Leptospira interrogans